3-Isopropylphenol → HCID 67238562, compound

HRID 2363085Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[C:16]([F:23])[C:17]=1[NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[CH2:5][NH:6][C:7]([C:9]1[N:10]=[C:11](Cl)[O:12][CH:13]=1)=[O:8].[CH:24]([C:27]1[CH:28]=[C:29]([OH:33])[CH:30]=[CH:31][CH:32]=1)([CH3:26])[CH3:25]>>[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[C:16]([F:23])[C:17]=1[NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[CH2:5][NH:6][C:7]([C:9]1[N:10]=[C:11]([O:33][C:29]2[CH:30]=[CH:31][CH:32]=[C:27]([CH:24]([CH3:26])[CH3:25])[CH:28]=2)[O:12][CH:13]=1)=[O:8]

Participants

Reactant 2

HCID 120593-Isopropylphenol

HCID 67111144HCID 67111144, compound

Product 1

HCID 67238562HCID 67238562, compoundYield 72.3%

Procedure

2-Chloro-oxazole-4-carboxylic acid 3,5-difluoro-4-methanesulfonylamino-benzylamide (38 mg, 0.11 mmol) was reacted with 3-isopropyl phenol (18 mg, 0.12 mmol) to give the title compound (37 mg, 70%) after purification by column chromatography (gradient 12% to 100% EtOAc in n-hexane).

Sources & evidence

ORD record: ord-0fbbf87697784f22a1fd81e8d3e3fa65
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08691855B2

Reaction notes

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