Sodium Cyanide → (4-tert-Butylphenyl)acetonitrile

Participants

Reaction Steps

4-t-Butylbenzylbromide (903 mg, 3.98 mmol) was reacted with NaCN (210 mg, 4.30 mmol) in ethanol (10 ml) and H2O (2 ml) at 80° C. The reaction solvent was removed in vacuo. The residue was diluted with EtOAc and H2O and the aqueous layer was extracted with EtOAc. The combined organic layer was dried over MgSO4 and then concentrated in vacuo. The residue was purified with column chromatography to yield title compound (797 mg)

Provenance & Evidence