反应详情

A solution of 22.6 g of 5,6-diamino-1-propyl-2,4-(1H,3H)-pyrimidinedione in 50 ml of acetic acid was refluxed for 2 hours. 30 ml of ethanol was added. The received crystals were filtered off. Yield 19.8 g. The amide was refluxed in 80 ml of 2N NaOH for 2 hours and then neutralized with 5N HCl. The crystals were filtered off and recrystallized from 2.1 l ethanol. Yield 9.8 g (38%) (XXXXVI) NMR (see Table I).

1. filtrationThe received crystals were filtered off
2. temperatureThe amide was refluxed in 80 ml of 2N NaOH for 2 hours
3. filtrationThe crystals were filtered off
4. customrecrystallized from 2.1 l ethanol