Acetic Acid → 3,7-dihydro-3-butyl-8-methyl-1H-purine-2,6-dione

HRID 236310Notes

Reaction equation

HRID 236310 reaction equation
[CH2:1]([N:5]1[C:10]([NH2:11])=[C:9]([NH2:12])[C:8](=[O:13])[NH:7][C:6]1=[O:14])[CH2:2][CH2:3][CH3:4].[C:15](O)(=O)[CH3:16]>>[CH2:1]([N:5]1[C:10]2[N:11]=[C:15]([CH3:16])[NH:12][C:9]=2[C:8](=[O:13])[NH:7][C:6]1=[O:14])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 105841085,6-Diamino-1-butylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 202170433,7-dihydro-3-butyl-8-methyl-1H-purine-2,6-dione

Procedure

A solution of 7.6 g of 1-butyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione in 20 ml of acetic acid was refluxed for 2 hours. The solution was evaporated. The residue was refluxed in 40 ml of 2N NaOH for 2 hours and then neutralized with 5N HCl. The crystals were filtered off and recrystallized from 350 ml ethanol.

Workup

  1. customThe solution was evaporated
  2. temperatureThe residue was refluxed in 40 ml of 2N NaOH for 2 hours
  3. filtrationThe crystals were filtered off
  4. customrecrystallized from 350 ml ethanol

Sources & evidence

ORD record
ord-becc659e2d044d028ad5db69f68447c1
Source dataset
uspto-grants-1987_02
Patent number
US04644001

Reaction notes

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