1-Methyl-2,3-dihydro-1H-inden-4-ol → HCID 44603002, compound

HRID 2363105Notes

Reaction equation

HRID 2363105 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21](Cl)[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10].[CH3:25][CH:26]1[C:34]2[CH:33]=[CH:32][CH:31]=[C:30]([OH:35])[C:29]=2[CH2:28][CH2:27]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21]([O:35][C:30]3[CH:31]=[CH:32][CH:33]=[C:34]4[C:29]=3[CH2:28][CH2:27][CH:26]4[CH3:25])[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 893101-Methyl-2,3-dihydro-1H-inden-4-olHCID 671108872-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide

Product 1

HCID 44603002HCID 44603002, compoundYield 63%

Procedure

2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (50 mg, 0.13 mmol) was reacted with 1-methyl-indan-4-ol (39 mg, 0.26 mmol) to give the title compound (40 mg, 63%) after purification by column chromatography (gradient 12% to 100% EtOAc in n-hexane).

Sources & evidence

ORD record
ord-2b8608db2e87487b98990c42d6afb786
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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