3,5-Bis(trifluoromethyl)phenol → HCID 86654776, compound

HRID 2363113Notes

Reaction equation

HRID 2363113 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21](Cl)[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10].[F:25][C:26]([F:39])([F:38])[C:27]1[CH:28]=[C:29]([OH:37])[CH:30]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:32]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21]([O:37][C:29]3[CH:30]=[C:31]([C:33]([F:34])([F:35])[F:36])[CH:32]=[C:27]([C:26]([F:25])([F:38])[F:39])[CH:28]=3)[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 676803,5-Bis(trifluoromethyl)phenolHCID 671108872-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide

Product 1

HCID 86654776HCID 86654776, compoundYield 65.4%

Procedure

2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (30 mg, 0.08 mmol) was reacted with 3,5-bis(trifluoromethyl)-phenol (30 mg, 0.13 mmol) to give the title compound (30 mg, 65%) after purification by flash chromatography on silica gel (gradient 12% to 100% EtOAc in n-hexane).

Sources & evidence

ORD record
ord-9186c6b5bac64d8cab574203c28ffea4
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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