4-Hydroxy-1-indanone → HCID 67111152, compound

Participants

Reaction Steps

To a suspension of CH3CH2PPh3I (677 mg, 1.62 mmol) in Et2O (10 mL) was added t-BuOK (181 mg, 1.62 mmol). The mixture was stirred for 15 minutes, to which was added dropwise 4-hydroxy-indan-1-one (200 mg, 1.35 mmol). The mixture was stirred at room temperature overnight and then diluted with diethylether. The mixture was filtered on a pad of celite, and the filtrate was concentrated. The crude residue was purified by column chromatography to give 1-ethylidene-indan-4-ol (37 mg, 17%).

Provenance & Evidence