HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 19854149, compound → 2-Propyl-5-(trifluoromethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 19854149 | HCID 19854149 | — |
| Reactant | HCID 19989023 | HCID 19989023 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Propyl-5-(trifluoromethyl)phenol | HCID 58319242 | 87.5% |
Reaction Steps
A mixture of 2-allyl-5-trifluoromethyl-phenol (60 mg, 12%) and 2-allyl-3-trifluoromethyl-phenol and 10% Pd/C (20 mg) in methanol (4 ml) was hydrogenated under 50 psi hydrogen atmosphere for 1 hour. The mixture was dissolved in EtOAc, filtered through a celite pad. The filtrate was concentrated under reduced pressure, and dried to give 2-propyl-5-trifluoromethyl-phenol (53 mg, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691855B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-4833c5b632064c5fa211fc7140850fcd |
| Source note | uspto-grants-2014_04 |