HCID 58319215, compound → HCID 44603127, compound

HRID 2363152Notes

Reaction equation

HRID 2363152 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21](Cl)[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10].[F:25][C:26]([F:38])([F:37])[CH:27]1[C:35]2[CH:34]=[CH:33][CH:32]=[C:31]([OH:36])[C:30]=2[CH2:29][CH2:28]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21]([O:36][C:31]3[CH:32]=[CH:33][CH:34]=[C:35]4[C:30]=3[CH2:29][CH2:28][CH:27]4[C:26]([F:25])([F:37])[F:38])[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 58319215HCID 58319215, compoundHCID 671108872-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide

Product 1

HCID 44603127HCID 44603127, compoundYield 87.4%

Procedure

2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (50 mg, 0.13 mmol) was reacted with 1-trifluoromethyl-indan-4-ol (53 mg, 0.26 mmol) to give the title compound (62 mg, 87%) after purification by column chromatography (gradient 12% to 100% EtOAc in n-hexane).

Sources & evidence

ORD record
ord-d2714d7d712c4aefaa660a339c5a56b4
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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