HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 86654783, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3,5-Bis-trifluoromethylphenylboronic acid | HCID 156265 | — |
| Reactant | HCID 67110925 | HCID 67110925 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | HCID 86654783 | HCID 86654783 | 28.2% |
Reaction Steps
3,5-Bis(trifluoromethyl)phenylboronic acid (67.1 mg, 0.26 mmol) and 2-chloro-thiazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylaminophenyl)-ethyl]-amide (50 mg, 0.13 mmol) was reacted using Pd(PPh3)2Cl2 (7 mg, 0.01 mmol), Cs2CO3 (127 mg, 0.39 mmol) as described above to give the title compound (21 mg, 28%) after purification by flash chromatography on silica gel (hexane: EtOAc=1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691855B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-5249da637df444f8bf3bf87ec50fd66a |
| Source note | uspto-grants-2014_04 |