HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 44603248, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-(Trifluoromethyl)phenylboronic acid | HCID 2734388 | — |
| Reactant | HCID 67110925 | HCID 67110925 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | HCID 44603248 | HCID 44603248 | 52.2% |
Reaction Steps
3-Trifluoromethylphenylboronic acid (62.7 mg, 0.33 mmol) and 2-chloro-thiazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (44.6 mg, 0.11 mmol) was reacted using Pd(PPh3)2Cl2 (10.5 mg, 0.015 mmol), Cs2CO3 (143.4 mg, 0.44 mmol) as described above to give the title compound (29 mg, 44%) after purification by flash chromatography on silica gel (hexane: EtOAc=1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691855B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-39ffd3bb2f4a418285f668d239913d0c |
| Source note | uspto-grants-2014_04 |