HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloro-5-(trifluoromethyl)benzene → 1-Chloro-3-cyclopropyl-5-(trifluoromethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloro-5-(trifluoromethyl)benzene | HCID 35361 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Tricyclohexylphosphine | HCID 75806 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | 1-Chloro-3-cyclopropyl-5-(trifluoromethyl)benzene | HCID 67110924 | 87.1% |
Reaction Steps
3,5-Dichlorobenzotrifluoride (1.10 g, 5.1 mmol) and cyclopropylboronic acid (440 mg, 5.1 mmol) were reacted using K3PO4 (3.8 g, 17.9 mmol), tricyclohexylphosphine (145 mg, 0.51 mmol), Pd(OAc)2 (60 mg, 0.27 mmol) as described in example 100 to give 1-chloro-3-cyclopropyl-5-trifluoromethyl-benzene (980 mg, 87%) after purification by flash chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691855B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-f35752fe12fa40f99a6f2d2e92dfff17 |
| Source note | uspto-grants-2014_04 |