HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 44603249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide | HCID 67110887 | — |
| Reactant | HCID 67111193 | HCID 67111193 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | HCID 44603249 | HCID 44603249 | 33.3% |
Reaction Steps
2-(3-Cyclopropyl-phenyl)-4,4,5,5-tetramethyl-[1,3]dioxolane (63 mg, 0.26 mmol) and 2-chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (50 mg, 0.13 mmol) was reacted using Pd(PPh3)2Cl2 (7 mg, 0.01 mmol), Cs2CO3 (127 mg, 0.39 mmol) as described above to give the title compound (20 mg, 33%) after purification by flash chromatography on silica gel (% EtOAc in hexane=25%˜100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691855B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-ef8bce9b76904a39887c613d138ae46b |
| Source note | uspto-grants-2014_04 |