Citric Acid → HCID 86662969, compound

HRID 2363241Notes

Reaction equation

[CH:1]#[C:2][CH2:3][NH:4][C@H:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6]1.[C:14]([OH:26])(=[O:25])[CH2:15][C:16]([CH2:21][C:22]([OH:24])=[O:23])([C:18]([OH:20])=[O:19])[OH:17]>>[CH:1]#[C:2][CH2:3][NH:4][C@H:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6]1.[C:14]([O-:26])(=[O:25])[CH2:15][C:16]([CH2:21][C:22]([O-:24])=[O:23])([C:18]([O-:20])=[O:19])[OH:17]

Participants

Reactant 2

HCID 311Citric Acid

HCID 3052776Rasagiline

Product 1

HCID 86662969HCID 86662969, compound

Procedure

The experiments conducted in this example are listed below in Table 4. In each of the experiments, rasagiline free base, excipient, and citric acid were combined and mixed in the corresponding solvent. A solid dispersion was prepared from the mixture by lyophilization at conditions listed in Table 4 below.

Workup

additionmixed in the corresponding solvent
customA solid dispersion was prepared from the mixture by lyophilization at conditions

Sources & evidence

ORD record: ord-81901a6b362d4da5870cae239ceb9382
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08691872B2

Reaction notes

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