HCID 86738404, compound → HCID 13770480, compound

HRID 236327Notes

Reaction equation

HRID 236327 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]2[CH:13]=[C:14]([CH:16]=[N:17]O)[N:15]=[C:5]2[C:4]1=[O:19])[CH3:2]>C(OC(=O)C)(=O)C>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]2[CH:13]=[C:14]([C:16]#[N:17])[N:15]=[C:5]2[C:4]1=[O:19])[CH3:2]

Participants

3

Reactant 1

HCID 86738404HCID 86738404, compound

Product 1

HCID 13770480HCID 13770480, compoundYield 103.5%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 0.4 g of the product of Step A in 5 ml of acetic anhydride was refluxed for 21/2 hours and was then cooled during which it solidified into a buff crystalline solid. The solid was triturated with aqueous sodium carbonate solution and was filtered. The product was washed with water and dried in vacuo to obtain 0.385 g of 4,5-dihydro-5-ethyl-4-oxo-imidazo-[1,2-a]-quinoxaline-2-carbonitrile in the form of a crystalline solid melting at >330° C.

Workup

  1. temperaturewas then cooled during which it
  2. customThe solid was triturated with aqueous sodium carbonate solution
  3. filtrationwas filtered
  4. washThe product was washed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-d1a142945a324ffa96a416917a4855a0
Source dataset
uspto-grants-1987_02
Patent number
US04644002

Reaction notes

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