反应详情

A mixture of 2.5 g (9.8 mmole) of the product of Step A in 40 ml of acetic acid anhydride was refluxed for 3 hours and was then poured into a mixture of water-sodium carbonate-ethyl acetate. The decanted organic phase was washed once with water, dried, filtered and evaporated to dryness. The residue was triturated with ether to obtain 1.8 g of 4,5-dihydro-5-ethyl-4-oxopyrrolo-[1,2-a]-quinoxaline-2-carbonitrile in the form of buff needles melting at 237°-239° C.

1. temperaturewas refluxed for 3 hours
2. washThe decanted organic phase was washed once with water
3. customdried
4. filtrationfiltered
5. customevaporated to dryness
6. customThe residue was triturated with ether