Ethylamine → HCID 71143550, compound

HRID 2363317Notes

Reaction equation

HRID 2363317 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH2:11]([NH2:13])[CH3:12].Cl.Cl.C[Si](C)(C)CCOC[N:22]1[C:26]2[N:27]=[CH:28][N:29]=[C:30]([C:31]3[CH:32]=[N:33][N:34]([C:36]4([CH2:40][C:41]#[N:42])[CH2:39][NH:38][CH2:37]4)[CH:35]=3)[C:25]=2[CH:24]=[CH:23]1>>[C:41]([CH2:40][C:36]1([N:34]2[CH:35]=[C:31]([C:30]3[C:25]4[CH:24]=[CH:23][NH:22][C:26]=4[N:27]=[CH:28][N:29]=3)[CH:32]=[N:33]2)[CH2:39][N:38]([C:2]2[CH:3]=[CH:4][C:5]([C:8]([NH:13][CH2:11][CH3:12])=[O:10])=[N:6][CH:7]=2)[CH2:37]1)#[N:42]

Participants

4

Reactant 3

HCID 6341EthylamineHCID 6085445-Bromopyridine-2-carboxylic acidHCID 67391464{3-[4-(7-{[2-(Trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile dihydrochloride

Product 1

HCID 71143550HCID 71143550, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 3, Step 1-3 starting from 5-bromopyridine-2-carboxylic acid, ethylamine (2.0 M in tetrahedrofuran solution) and {3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile dihydrochloride. LCMS (M+H)+: m/z=428.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-826626772df7403db5a22a75f2f07b13
Source dataset
uspto-grants-2014_04
Patent number
US08691807B2

Reaction notes

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