HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Ethoxy-5-oxo-tetrahydrofuran-3-yl)-carbamic acid allyl ester → HCID 22977481, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Ethoxy-5-oxo-tetrahydrofuran-3-yl)-carbamic acid allyl ester | HCID 22149038 | — |
| Reactant | 1-[2-(4-Amino-3-chloro-benzoylamino)-propionyl]-pyrrolidine-2-carboxylic acid (5-oxo-2-phenethyloxy-tetrahydro-furan-3-yl)-amide | HCID 22977512 | — |
| Product | HCID 22977481 | HCID 22977481 | — |
Reaction Steps
Prepared from (2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-carbamic acid allyl ester and 97b following the method used for 98a. The title compound was isolated as a white solid (51 mg, 18% yield). 1H-NMR (500 MHz, 1:1 CDCl3:CD3OD) δ 1.08-1.35 (m, 3H), 1.35-1.55 (m, 3H), 1.75-2.44 (m, 4H), 2.26 (s, 3H), 2.44-3.07 (m, 2H), 3.48-3.97 (m, 2H), 4.18-4.92 (m, 5H), 5.32 (d, 0.4H), 5.47 (d, 0.1H), 5.58 (d, 0.4H), 5.64 (d, 0.1H), 7.70-8.35 (m, 3H). Analytical HPLC 10.37, 10.54 min. LC-MS (ES+) m/e=509.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691848B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-a19191e704c94231a7cc379b0a614696 |
| Source note | uspto-grants-2014_04 |