L-Tartaric acid → HCID 66997652, compound

Participants

Reaction Steps

(3aR,4S,6aS)-2-Benzyloctahydrocyclopenta[c]pyrrol-4-amine (1.26 g, 5.82 mmol) from Step 2 and ethanol (12 mL) were combined. L-Tartaric acid in ethanol (4.7 mL) was added to the reaction solution over 2 hours. The resulting slurry was further diluted with ethanol (10 mL). The slurry was filtered and the cake was rinsed with ethanol (10 mL) to provide (3aR,4S,6aS)-2-benzyloctahydrocyclopenta-[c]pyrrol-4-amine(2R,3R)-2,3-dihydroxysuccinate: 1H NMR (400 MHz, dimethyl sulfoxide-d6) δ ppm 7.37-7.30 (m, 4H), 7.29-7.24 (m, 1H) 3.91 (s, 2H), 3.56 (q, J=13.2, 2H), 3.19 (dt, J=5.4, 7.4, 1H), 2.71-2.61 (m, 2H), 2.50-2.41 (m, 2H), 2.36-2.28 (m, 2H), 2.05-1.95 (m, 2H), 1.65-1.55 (m, 1H), 1.43-1.33 (m, 1H).

Provenance & Evidence