HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → beta-Oxo-alpha-(2,4-difluorophenylcarbamoyl)-beta-(2-pyrrolyl)-propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-Difluorophenyl isocyanate | HCID 593258 | — |
| Reactant | 3-oxo-3-(1H-pyrrol-2-yl)propanenitrile | HCID 11194355 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | beta-Oxo-alpha-(2,4-difluorophenylcarbamoyl)-beta-(2-pyrrolyl)-propionitrile | HCID 13370091 | — |
Reaction Steps
Reaction of 2.4 g of 2-pyrroloylacetonitrile with 3.1 g of 2,4-difluorophenyl isocyanate in the presence of 2.0 g Et3N in 25 ml of glyme and isolation similarly to the preceding examples, followed by trituration with and recrystallization from ethanol gives β-oxo-α-(2,4-difluorophenylcarbamoyl)-β-(2-pyrrolyl)-propionitrile, m.p. 169°-171°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04644010 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-7872158a0ff5484c81ade8ebaa73e201 |
| Source note | uspto-grants-1987_02 |