Reaction Steps
The title compound was prepared by substituting 2-(trifluoromethyl)benzaldehyde for 3-(trifluoromethyl)benzaldehyde and 3-methyl-N-[(3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide from Example 83 Step A for 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide in the procedure described for Example 54: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.61 (d, J=6.0, 1H), 7.93 (d, J=7.6, 0.5H), 7.85 (d, J=7.8, 0.5H), 7.63 (t, J=5.8, 3H), 7.53 (dd, J=7.9, 16.0, 1H), 7.38-7.23 (m, 5H), 4.36 (dd, J=5.7, 13.2, 1H), 3.76 (q, J=14.5, 1H), 3.66 (q, J=15.0, 1H), 3.23 (dd, J=2.2, 10.5, 1H), 3.03 (dd, J=2.2, 9.0, 0.5H), 2.69-2.60 (m, J=5.6, 17.6, 1H), 2.59-2.47 (m, 1H), 2.47-2.40 (m, J=10.2, 17.4, 1H), 2.39-2.12 (m, 3H), 1.96-1.82 (m, 1H), 1.78 (dt, J=6.2, 20.1, 0.5H), 1.68 (dt, J=7.2, 13.8, 0.5H), 1.48-1.24 (m, 1.5H), 1.20 (t, J=6.7, 3H), 0.70 (dd, J=1.7, 6.7, 3H); MS (ESI+) m/z 445 (M+H)+.
