Reaction Steps
The title compound was prepared by substituting 3-(3-(trifluoromethyl)phenyl)propanal for 3-(trifluoromethyl)benzaldehyde and 3-methyl-N-[(3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide from Example 83 Step A for 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide in the procedure described for Example 54: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.61 (d, J=6.4, 1H), 7.69-7.62 (m, 3H), 7.53 (d, J=6.5, 1H), 7.46 (t, J=7.8, 1H), 7.42 (d, J=5.5, 1H), 7.34 (t, J=7.5, 2H), 7.26 (t, J=7.3, 1H), 4.37 (tt, J=6.4, 12.7, 1H), 3.24 (d, J=10.5, 1H), 3.00 (dd, J=1.9, 8.9, 0.5H), 2.78-2.63 (m, 3H), 2.61 (dd, J=2.3, 9.1, 0.5H), 2.57-2.45 (m, 1H), 2.40 (dd, J=7.1, 14.3, 0.5H), 2.37-2.26 (m, 3H), 2.24-2.07 (m, 3H), 1.93-1.83 (m, 1H), 1.83-1.71 (m, 2H), 1.71-1.63 (m, 1H), 1.48-1.37 (m, 1H), 1.37-1.30 (m, 0.5H), 1.23 (dd, J=6.5, 13.6, 3H), 0.72 (dd, J=4.4, 6.6, 3H); MS (ESI+) m/z 473 (M+H)+.
