Reaction Steps
The title compound was prepared by substituting 3-(4-(trifluoromethyl)phenyl)propanal for 3-(trifluoromethyl)benzaldehyde and 3-methyl-N-[(3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide from Example 83 Step A for 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide in the procedure described for Example 54: 1H NMR (500 MHz, pyridine-d5) δ ppm 7.69-7.62 (m, 4H), 7.39 (d, J=8.0, 1H), 7.37-7.32 (m, 3H), 7.26 (t, J=7.3, 1H), 4.41-4.33 (m, 1H), 3.25 (d, J=10.5, 1H), 3.00 (dd, J=2.2, 9.0, 0.5H), 2.76-2.59 (m, 3H), 2.56-2.46 (m, 1H), 2.44-2.39 (m, 0.5H), 2.37 (dd, J=2.1, 8.9, 0.5H), 2.31 (dt, J=5.8, 14.1, 2H), 2.23-2.07 (m, 3H), 1.94-1.71 (m, 2.5H), 1.67 (ddd, J=5.6, 7.9, 11.8, 1H), 1.47-1.28 (m, 2H), 1.23 (dd, J=6.5, 13.1, 3H), 0.89 (dt, J=7.2, 24.8, 1H), 0.72 (dd, J=3.7, 6.7, 3H); MS (ESI+) m/z 473 (M+H)+.
