1-Phenylcyclopentanecarboxylic acid → HCID 66589969, compound

HRID 2363533Notes

Reaction equation

HRID 2363533 reaction equation
[C:1]1([C:7]2([C:12]([OH:14])=O)[CH2:11][CH2:10]CC2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15]1([C@@H:21]([N:23]2[CH2:27][C@H:26]3[CH:28]([NH2:31])[CH2:29][CH2:30][C@H:25]3[CH2:24]2)[CH3:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N1C[C@H]2C(N)CC[C@H]2C1)C1C=CC=CC=1>>[C:1]1([C@H:7]([CH2:11][CH3:10])[C:12]([NH:31][C@H:28]2[C@H:26]3[C@H:25]([CH2:24][N:23]([C@H:21]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH3:22])[CH2:27]3)[CH2:30][CH2:29]2)=[O:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 661671-Phenylcyclopentanecarboxylic acidHCID 66590867HCID 66590867, compoundHCID 68411161(3aS*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine

Product 1

HCID 66589969HCID 66589969, compound

Procedure

The title compounds were prepared by substituting (S)-2-phenylbutanoic acid for 1-phenylcyclopentanecarboxylic acid and (3aS,6aR)-2-((S)-1-phenylethyl)octahydrocyclopenta[c]pyrrol-4-amine for (3aS*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Examples 1 and 2.

Sources & evidence

ORD record
ord-c53d1953d9324cb787d5fd003ac3175b
Source dataset
uspto-grants-2014_04
Patent number
US08691865B2

Reaction notes

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