Reaction Steps
The title compound was prepared by substituting (S)-4-methyl-2-(neopentylamino)pentanoic acid from Step A of Example 244 for N-(tert-butoxycarbonyl)-L-leucine and (3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine of Step E from Example 16 for (3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 221: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.07-8.09 (m, 1H), 7.43-7.45 (m, 2H), 7.37 (t, J=7.5 Hz, 2H), 7.28 (t, J=7.3 Hz, 1H), 4.43 (p, J=6.2 Hz, 1H), 3.60 (d, J=13.1 Hz, 1H), 3.45 (d, J=13.1 Hz, 1H), 3.26 (dd, J=8.6, 5.6 Hz, 1H), 2.86 (dd, J=8.9, 2.6 Hz, 1H), 2.47-2.60 (m, 2H), 2.42-2.47 (m, 2H), 2.36 (dd, J=9.1, 3.0 Hz, 1H), 2.29-2.35 (m, 1H), 2.29 (dd, J=8.7, 7.3 Hz, 1H), 2.14 (dq, J=12.1, 6.0 Hz, 1H), 1.81-1.95 (m, 2H), 1.52-1.76 (m, 4H), 1.44 (dq, J=13.2, 6.6 Hz, 1H), 0.94 (s, 9H), 0.93 (d, J=6.6 Hz, 3H), 0.87 (d, J=6.5 Hz, 3H); MS (ESI+) m/z 400 (M+H)+.
