Reaction Steps
The title compound was prepared by substituting (S)-4-methyl-2-(neopentylamino)pentanoic acid from Step A of Example 244 for N-(tert-butoxycarbonyl)-L-leucine and (3aS,4R,6aR)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-amine from Step A for (3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 221: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.37-8.38 (bs, 1H), 8.15-8.19 (m, 2H), 7.90-7.92 (m, 1H), 7.71 (t, J=7.8 Hz, 1H), 4.22-4.28 (m, 1H), 3.88 (dd, J=9.9, 2.8 Hz, 1H), 3.23 (dd, J=8.5, 5.7 Hz, 1H), 3.19 (dd, J=9.7, 2.8 Hz, 1H), 3.15 (dd, J=9.9, 7.6 Hz, 1H), 2.96 (dd, J=9.6, 7.2 Hz, 1H), 2.50-2.59 (m, 2H), 2.41-2.44 (m, 1H), 2.32 (d, J=11.2 Hz, 1H), 1.92-2.01 (m, 1H), 1.82-1.92 (m, 2H), 1.60-1.78 (m, 1H), 1.69 (ddd, J=13.5, 7.8, 5.7 Hz, 1H), 1.50-1.59 (m, 2H), 1.32 (ddt, J=9.4, 13.0, 6.5 Hz, 1H), 0.92 (s, 9H), 0.92 (d, J=6.6 Hz, 3H), 0.86 (d, J=6.5 Hz, 3H); MS (ESI+) m/z 518 (M+H)+.
