Reaction Steps
The title compound was prepared by substituting N-(tert-butoxycarbonyl)-N-methyl-L-leucine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[3-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 605 Step B for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.34 (d, J=7.4, 1H), 7.34 (t, J=7.9, 1H), 7.06 (d, J=7.6, 1H), 6.94 (s, 1H), 6.78 (dd, J=8.3, 2.2, 1H), 4.46-4.38 (m, 1H), 3.55 (dd, J=9.9, 2.8, 1H), 3.37-3.32 (m, 1H), 3.27 (dd, J=8.3, 5.8, 1H), 3.17 (dd, J=9.5, 7.9, 1H), 3.01 (dd, J=9.7, 3.3, 1H), 2.79-2.70 (m, 2H), 2.46 (s, 3H), 0.2-1.86 (br s, 1H), 2.13 (dt, J=12.5, 6.7, 1H), 2.01-1.87 (m, 2H), 1.79-1.65 (m, 2H), 1.65-1.57 (m, 1H), 1.46-1.38 (m, 1H), 0.94 (d, J=6.6, 3H), 0.88 (d, J=6.6, 3H); MS (ESI+) m/z 398 (M+H)+.
