(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66996537, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-N-methyl-L-leucine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.34 (d, J=7.4, 1H), 7.57 (d, J=4.2, 2H), 6.63 (d, J=8.7, 2H), 4.44-4.37 (m, 1H), 3.56 (dd, J=10.2, 2.9, 1H), 3.39 (dd, J=10.0, 7.6, 1H), 3.30-3.21 (m, 2H), 3.03 (dd, J=9.9, 3.5, 1H), 2.79-2.68 (m, 2H), 2.47 (s, 3H), 2.12 (dt, J=12.4, 6.9, 1H), 2.08-2.01 (m, 1H), 2.00-1.88 (m, 2H), 1.79-1.57 (m, 3H), 1.39 (dtd, J=13.1, 8.0, 5.1, 1H), 0.94 (d, J=6.6, 3H), 0.88 (d, J=6.6, 3H); MS (ESI+) m/z 398 (M+H)+.

Provenance & Evidence