(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66997021, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-N-methyl-L-norvaline for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-(3-(trifluoromethoxy)phenyl)octahydrocyclopenta[c]pyrrol-4-amine from Example 715 Step 1 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (400 MHz, pyridine-d5, temperature 90° C.) δ ppm 7.63-7.68 (bs, 1H), 7.18 (t, J=8.4 Hz, 1H), 6.60-6.64 (m, 1H), 6.51-6.54 (m, 2H), 4.27 (dt, J=13.2, 6.6 Hz, 1H), 3.47 (dd, J=9.9, 3.8 Hz, 1H), 3.35 (dd, J=9.9, 7.9 Hz, 1H), 3.22 (dd, J=9.6, 8.0 Hz, 1H), 3.10 (dd, J=6.9, 5.8 Hz, 1H), 3.01 (dd, J=9.6, 4.1 Hz, 1H), 2.63-2.80 (m, 2H), 2.39 (s, 3H), 2.05-2.13 (m, 1H), 1.92-2.01 (m, 1H), 1.74-1.83 (m, 1H), 1.58-1.69 (m, 2H), 1.37-1.54 (m, 3H), 0.88 (t, J=7.3 Hz, 3H); MS (ESI+) m/z 400 (M+H)+.

Provenance & Evidence