(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66997446, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-N-methyl-L-norvaline for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-(4-(trifluoromethoxy)phenyl)octahydrocyclopenta[c]pyrrol-4-amine from Example 716 Step 1 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (400 MHz, pyridine-d5, temperature 90° C.) δ ppm 7.60-7.71 (m, 1H), 7.10-7.15 (m, 2H), 6.56-6.59 (m, 2H), 4.24-4.32 (m, 1H), 3.47 (dd, J=9.9, 3.6 Hz, 1H), 3.31 (dd, J=9.8, 7.9 Hz, 1H), 3.19 (dd, J=9.5, 7.9 Hz, 1H), 3.10 (dd, J=6.9, 5.8 Hz, 1H), 3.01 (dd, J=9.6, 4.0 Hz, 1H), 2.71-2.83 (m, 1H), 2.56-2.70 (m, 1H), 2.40 (s, 3H), 2.09 (dq, J=12.6, 6.3 Hz, 1H), 1.92-2.01 (m, 1H), 1.74-1.83 (m, 1H), 1.58-1.70 (m, 2H), 1.38-1.53 (m, 3H), 0.88 (t, J=7.3 Hz, 3H); MS (ESI+) m/z 400 (M+H)+.

Provenance & Evidence