Reaction Steps
The title compound was prepared by substituting tert-butyl methyl((S)-4-methyl-1-((3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxopentan-2-yl)carbamate from Example 619 Step 1 for (2S,4S)-tert-butyl 4-fluoro-2-((3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-ylcarbamoyl)pyrrolidine-1-carboxylate and 4-chloro-2-(trifluoromethyl)pyrimidine for 2-bromo-4-(trifluoromethyl)pyridine in the procedure described in Example 637: 1H NMR (400 MHz, pyridine-d5) δ ppm 8.23 (d, J=6.1, 1H), 7.73 (dd, J=6.7, 4.2, 1H), 6.34 (d, J=6.1, 1H), 4.25 (dt, J=14.3, 7.2, 1H), 3.73-3.52 (m, 3H), 3.28 (dd, J=11.2, 4.0, 1H), 3.15 (dd, J=7.9, 5.8, 1H), 2.83-2.65 (m, 2H), 2.39 (d, J=0.5, 3H), 2.13 (td, J=12.5, 7.3, 1H), 2.01-1.90 (m, 1H), 1.93-1.67 (br m, 1H), 1.85 (td, J=13.4, 6.6, 1H), 1.74-1.60 (m, 2H), 1.52 (ddd, J=14.0, 7.9, 6.3, 1H), 1.41 (td, J=13.3, 7.9, 1H), 0.93 (d, J=6.6, 3H), 0.89 (d, J=6.6, 3H); MS (ESI+) m/z 400 (M+H)+.
