(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66997603, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-L-glycine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.27 (d, J=6.9, 1H), 7.58 (d, J=8.7, 2H), 6.61 (d, J=8.7, 2H), 4.39-4.29 (m, 1H), 3.57 (s, 2H), 3.51 (dd, J=10.2, 3.4, 1H), 3.30 (dd, J=10.0, 7.9, 1H), 3.20 (dd, J=9.6, 8.4, 1H), 3.00 (dd, J=9.9, 4.2, 1H), 2.69 (ddd, J=16.0, 8.3, 4.3, 1H), 2.66-2.59 (m, 1H), 2.51-2.17 (bs, 2H), 2.11-2.01 (m, 1H), 1.91 (dtd, J=13.0, 7.9, 5.0, 1H), 1.61 (dq, J=12.6, 8.0, 1H), 1.41-1.29 (m, 1H); MS (ESI+) m/z 328 (M+H)+.

Provenance & Evidence