(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66997212, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-N-methyl-L-glycine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (400 MHz, pyridine-d5) δ ppm 8.11 (d, J=7.3, 1H), 7.57 (d, J=8.6, 2H), 6.61 (d, J=8.7, 2H), 4.42-4.27 (m, 1H), 3.51 (dd, J=10.2, 3.3, 1H), 3.42 (d, J=1.0, 2H), 3.32 (dd, J=10.1, 7.8, 1H), 3.21 (dd, J=9.8, 8.1, 1H), 3.00 (dd, J=9.9, 4.1, 1H), 2.74-2.60 (m, 2H), 2.45-2.35 (bs, 1H), 2.40 (s, 3H), 2.08 (ddd, J=19.2, 7.0, 5.1, 1H), 1.92 (dtd, J=12.9, 7.9, 5.0, 1H), 1.62 (ddd, J=16.0, 12.6, 7.9, 1H), 1.42-1.27 (m, 1H); MS (ESI+) m/z 342 (M+H)+.

Provenance & Evidence