(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66996890, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-N-methyl-L-alanine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.16 (d, J=7.4, 1H), 7.57 (d, J=8.6, 2H), 6.62 (d, J=8.7, 2H), 4.36 (dd, J=13.0, 6.9, 1H), 3.53 (dd, J=10.2, 3.4, 1H), 3.39-3.33 (m, 1H), 3.29 (q, J=6.9, 1H), 3.22 (dd, J=9.7, 8.1, 1H), 3.01 (dd, J=9.9, 4.0, 1H), 2.77-2.63 (m, 2H), 2.42 (s, 3H), 2.20-2.13 (bs, 1H), 2.12-2.03 (m, 1H), 1.99-1.86 (m, 1H), 1.64 (dq, J=12.7, 7.9, 1H), 1.41 (d, J=6.8, 3H), 1.39-1.32 (m, 1H); MS (ESI+) m/z 356 (M+H)+.

Provenance & Evidence