(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 86659293, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-N,2-dimethyl-L-alanine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (400 MHz, pyridine-d5) δ ppm 7.95 (d, J=7.5, 1H), 7.57 (d, J=8.7, 2H), 6.61 (d, J=8.7, 2H), 4.33-4.21 (m, 1H), 3.50 (dd, J=10.2, 3.6, 1H), 3.33 (dd, J=10.1, 8.0, 1H), 3.21 (dd, J=9.7, 8.3, 1H), 3.00 (dd, J=9.9, 4.2, 1H), 2.75-2.65 (m, 1H), 2.65-2.55 (m, 1H), 2.32 (s, 3H), 2.06 (ddd, J=19.3, 7.0, 5.1, 1H), 2.04-1.96 (bs, 1H), 1.98-1.85 (m, 1H), 1.65-1.53 (m, 1H), 1.44 (s, 3H), 1.42 (s, 3H), 1.40-1.30 (m, 1H); MS (ESI+) m/z 370 (M+H)+.

Provenance & Evidence