(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66997531, compound

Participants

Reaction Steps

The title compound was prepared by substituting (S)-N-(tert-butoxycarbonyl)-2-aminobutyric acid for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.33 (d, J=7.1, 1H), 7.57 (d, J=8.7, 2H), 6.61 (d, J=8.7, 2H), 4.38-4.30 (m, 1H), 3.52 (ddd, J=12.9, 8.7, 4.2, 2H), 3.32 (dd, J=10.1, 7.9, 1H), 3.21 (dd, J=9.7, 8.1, 1H), 3.00 (dd, J=9.9, 4.1, 1H), 2.75-2.61 (m, 2H), 2.34-2.10 (m, 2H), 2.11-1.96 (m, 2H), 1.92 (dtd, J=13.1, 7.9, 5.1, 1H), 1.81-1.71 (m, 1H), 1.62 (dq, J=12.7, 7.9, 1H), 1.40-1.30 (m, 1H), 1.03 (t, J=7.4, 3H); MS (ESI+) m/z 356 (M+H)+.

Provenance & Evidence