(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66996954, compound

Participants

Reaction Steps

The title compound was prepared by substituting (S)-N-(tert-butoxycarbonyl)-N-methyl-L-norvaline for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.27 (d, J=7.4, 1H), 7.58 (d, J=8.3, 2H), 6.63 (d, J=8.7, 2H), 4.40 (dd, J=6.7, 5.4, 1H), 3.55 (dd, J=10.2, 3.1, 1H), 3.38 (dd, J=10.0, 7.6, 1H), 3.22 (ddd, J=10.5, 8.4, 7.0, 2H), 3.02 (dd, J=9.9, 3.7, 1H), 2.78-2.66 (m, 2H), 2.45 (s, 3H), 2.21-2.01 (m, 2H), 1.95 (ddd, J=12.9, 7.9, 2.7, 1H), 1.88-1.79 (m, 1H), 1.77-1.63 (m, 2H), 1.58-1.46 (m, 2H), 1.42-1.32 (m, 1H), 0.87 (t, J=7.4, 3H); MS (ESI+) m/z 384 (M+H)+.

Provenance & Evidence