(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66997207, compound

Participants

Reaction Steps

The title compound was prepared by substituting (S)-N-(tert-butoxycarbonyl)-N-methyl-D-leucine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.36 (d, J=7.4, 1H), 7.57 (d, J=8.6, 2H), 6.63 (d, J=8.7, 2H), 4.46-4.37 (m, 1H), 3.56 (dd, J=10.1, 3.0, 1H), 3.38 (dd, J=10.0, 7.6, 1H), 3.30-3.19 (m, 2H), 3.02 (dd, J=9.9, 3.7, 1H), 2.73 (ddd, J=13.1, 8.2, 6.7, 2H), 2.46 (s, 3H), 2.18-2.09 (m, 1H), 2.11-2.01 (m, 1H), 2.00-1.87 (m, 2H), 1.80-1.58 (m, 3H), 1.39 (dtd, J=13.2, 8.0, 5.2, 1H), 0.94 (d, J=6.6, 3H), 0.88 (d, J=6.6, 3H); MS (ESI+) m/z 398 (M+H)+.

Provenance & Evidence