(3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine → HCID 66997489, compound

Participants

Reaction Steps

The title compound was prepared by substituting 3-cyclopropyl-N-(tert-butoxycarbonyl)-N-methyl-L-alanine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-(4-(trifluoromethoxy)phenyl)octahydrocyclopenta[c]pyrrol-4-amine from Example 716 Step 1 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (400 MHz, pyridine-d5) δ ppm 8.28 (d, J=7.6, 1H), 7.22 (s, 2H), 6.65-6.54 (m, 2H), 4.46-4.36 (m, 1H), 3.55 (dd, J=9.9, 2.7, 1H), 3.35-3.24 (m, 2H), 3.15 (dd, J=9.5, 7.8, 1H), 3.02 (dd, J=9.6, 3.3, 1H), 2.79-2.67 (m, 2H), 2.46 (d, J=9.2, 3H), 2.17-2.05 (m, 1H), 2.02-1.91 (m, 1H), 1.84 (dd, J=30.5, 23.8, 1H), 1.83-1.62 (m, 3H), 1.45-1.35 (m, 1H), 0.99-0.86 (m, 1H), 0.53-0.38 (m, 2H), 0.19-0.07 (m, 2H); MS (ESI+) m/z 412 (M+H)+.

Provenance & Evidence