Reaction Steps
The title compound was prepared by substituting 3-cyclopropyl-N-(tert-butoxycarbonyl)-L-alanine for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-(4-(trifluoromethoxy)phenyl)octahydrocyclopenta[c]pyrrol-4-amine from Example 716 Step 1 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (400 MHz, pyridine-d5) δ ppm 8.33 (d, J=7.6, 1H), 7.20-7.18 (m, 2H), 6.62-6.54 (m, 2H), 4.40-4.32 (m, 1H), 3.71 (dd, J=7.4, 5.3, 1H), 3.52 (dd, J=9.9, 3.0, 1H), 3.24 (dd, J=9.8, 7.6, 1H), 3.13 (dd, J=9.6, 7.8, 1H), 3.00 (dd, J=9.6, 3.6, 1H), 2.77-2.60 (m, 2H), 2.33 (s, 2H), 2.08 (dt, J=12.2, 6.7, 1H), 1.99-1.83 (m, 2H), 1.73 (dt, J=13.9, 7.1, 1H), 1.63 (ddd, J=16.0, 12.4, 7.7, 1H), 1.37 (td, J=12.8, 7.1, 1H), 0.94 (dt, J=12.1, 4.9, 1H), 0.52-0.37 (m, 2H), 0.21-0.07 (m, 2H); MS (ESI+) m/z 398 (M+H)+.
