Reaction Steps
The title compound was prepared by substituting N-(tert-butoxycarbonyl)-trans-4-fluoro-L-proline for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-(5-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine from Example 262 Step B for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.65-8.59 (m, 1H), 8.33 (d, J=7.5 Hz, 1H), 7.67 (dd, J=8.9, 2.5 Hz, 1H), 6.36 (d, J=8.9 Hz, 1H), 5.20 (dt, J=54.4, 3.5 Hz, 1H), 4.36-4.23 (m, 2H), 3.75 (d, J=8.4 Hz, 1H), 3.66-3.52 (m, 3H), 3.30 (dt, J=15.2, 7.6 Hz, 2H), 2.91 (dd, J=38.5, 11.2 Hz, 1H), 2.77-2.68 (m, 1H), 2.68-2.52 (m, 2H), 2.25 (dddd, J=39.3, 14.8, 7.9, 4.4 Hz, 1H), 2.11 (ddd, J=19.5, 7.2, 4.9 Hz, 1H), 1.92 (dtd, J=13.0, 8.1, 4.8 Hz, 1H), 1.62 (dq, J=12.7, 8.2 Hz, 1H), 1.39 (dtd, J=13.4, 7.9, 5.7 Hz, 1H); MS (ESI+) m/z 387 (M+H)+.
