Reaction Steps
The title compound was prepared by substituting N-(tert-butoxycarbonyl)-trans-4-fluoro-L-proline for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-[4-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-4-amine from Example 607 for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.32 (d, J=7.5, 1H), 7.57 (d, J=7.7, 2H), 6.60 (d, J=8.7, 2H), 5.30-5.12 (m, 1H), 4.34-4.24 (m, 2H), 3.62 (s, 1H), 3.48 (dd, J=10.2, 3.5, 1H), 3.37-3.26 (m, 2H), 3.19 (dd, J=12.2, 5.8, 1H), 3.05-2.98 (m, 1H), 2.97-2.84 (m, 1H), 2.76-2.65 (m, 1H), 2.59 (dddd, J=14.7, 10.3, 8.4, 3.9, 2H), 2.26 (dddd, J=39.3, 14.8, 7.9, 4.4, 1H), 2.10-2.02 (m, 1H), 1.92 (dtd, J=13.0, 8.0, 5.0, 1H), 1.60 (dq, J=12.6, 8.0, 1H), 1.41-1.30 (m, 1H); MS (ESI+) m/z 386 (M+H)+.
