1-[4-(Thiophen-3-yl)phenyl]methanamine → HCID 68109328, compound

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Reaction Steps

According to the same conditions resulting in the preparation of the compound IIa.1, the compound IIa.3 is prepared from 8-isopropyl-4-(N-methyl-N-phenylamino)-2-(methylsulfanyl)pyrazolo[1,5-a]-1,3,5-triazine and from 4-(thiophen-3-yl)benzylamine. Yield=74%. Mp=141-143° C. (EtOH). 1H NMR (300 MHz, CDCl3): δ 7.73 (s, 1H, Harom), 7.57 (d, 2H, J=8.3 Hz, Harom), 7.45-7.36 (m, 5H, Harom), 6.78 (bs, 1H, NH), 4.81 (d, 2H, J=6.0 Hz, CH2), 3.16 (hept, 1H, J=7.0 Hz, CH), 2.58 (s, 3H, CH3), 1.33 (d, 6H, J=7.0 Hz, 2 CH3). MS (ESI): m/z 396 (MH+).

Provenance & Evidence