Fumaric Acid → (R)-2-(1,2-dihydroxypropan-3-ylamino)-8-isopropyl-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine fumarate

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Reaction Steps

The product 10 is treated with fumaric acid in an EtOH/Et2O solution. The fumaric acid salt 11 crystallizes from the reaction medium. Mp=168-170° C. 1H NMR (300 MHz, CDCl3 1 drop DMSO-d6): δ 8.64 (d, 1H, J=3.8 Hz, Harom), 7.93 (d, 2H, J=8.1 Hz, Harom), 7.74-7.65 (m, 2H, Harom), 7.60 (s, 1H, Harom), 7.42 (d, 2H, J=8.1 Hz, Harom), 7.26-7.18 (m, 1H, Harom), 6.76 (s, 2H, ═CH), 4.74 (d, 2H, J=5.9 Hz, CH2), 3.80-3.75 (m, 1H, CH), 3.56-3.45 (m, 4H, 2 CH2), 2.99 (hept, 1H, J=6.8 Hz, CH), 1.23 (d, 6H, J=6.8 Hz, 2 CH3).

Provenance & Evidence