HCID 44124141, compound → HCID 44124941, compound

HRID 2363733Notes

Reaction equation

HRID 2363733 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]2[N:11]([CH:13]=[C:14]([C:16]([O:18]CC)=[O:17])[N:15]=2)[CH:12]=1.CC(C)(OC(NC1N=C(C2C=CC3N(C=C(C(O)=O)N=3)C=2)C=CC=1)=O)C>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]2[N:11]([CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=2)[CH:12]=1

Participants

3

Reactant 2

HCID 44124141HCID 44124141, compoundHCID 441249406-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid

Product 1

HCID 44124941HCID 44124941, compoundYield 98.7%

Procedure

317 mg of ethyl 6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxylate are saponified under conditions similar to those described for the preparation of Intermediate 11 (step 11.3) to give 280 mg of 6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid in the form of a pasty pink solid.

Sources & evidence

ORD record
ord-f8d19d9f82e54663b1557f6686211257
Source dataset
uspto-grants-2014_04
Patent number
US08691990B2

Reaction notes

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