Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2363745Generated: October 30, 2026

Thiophene-3-boronic acid → Ethyl 6-(thiophen-3-yl)imidazo[1,2-a]pyridine-2-carboxylate

https://huagongshe.com/reaction/2363745

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiophene-3-boronic acidHCID 581760—
ReactantEthyl 6-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]imidazo[1,2-a]pyridine-2-carboxylateHCID 44136203—
ProductEthyl 6-(thiophen-3-yl)imidazo[1,2-a]pyridine-2-carboxylateHCID 44136336—

Reaction Steps

This product is prepared under conditions similar to those described for the preparation of Intermediate 15 (step 15.1), replacing the 1-(triisopropylsilyl)pyrrole-3-boronic acid with thiophene-3-boronic acid (catalyst: dichlorobis(triphenylphosphine)palladium).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08691990B2
Source datasetuspto-grants-2014_04
ORD IDord-061d156c2f80459e98227a8fb9b5cf3c
Source noteuspto-grants-2014_04