HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 2-(Chloromethyl)-3,4-dimethoxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 2-(Chloromethyl)-3,4-dimethoxypyridine | HCID 5079722 | — |
| Reactant | HCID 178506404 | HCID 178506404 | — |
| Product | 2-(Chloromethyl)-3,4-dimethoxypyridine | HCID 5079722 | — |
| Product | Pantoprazole | HCID 178493214 | — |
Reaction Steps
In one of the processes described in this patent application, 2-chloromethyl-3,4-dimethoxy pyridine was reacted with 2-mercapto-5-difluoromethoxy benzimidazole to prepare a precursor sulfide, which was isolated and oxidized by using metachloroperbenzoic acid to yield pantoprazole base in a yield of 102% by weight with respect to 2-chloromethyl-3,4 dimethoxy pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691995B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-ddbfc449942a4bb4a6d4634d47f5dbd1 |
| Source note | uspto-grants-2014_04 |