Hydrochloric Acid → HCID 66743147, compound

Participants

Reaction Steps

A mixture of methyl 3-(methylamino)-5-(pyridin-4-yl)thiophene-2-carboxylate (0.533 g, 2.15 mmol), sodium methoxide (0.348 g, 6.45 mmol), methanol (8.0 mL) and water (2.0 mL) was heated at reflux for 4 h. The mixture was cooled in an ice-bath and conc. HCl (0.533 mL, 6.45 mmol) was added to adjust the pH to 4. The resultant yellow precipitate was collected by filtration and washed with water and methanol to afford the title compound (0.342 g, 68%) as a yellow solid:

Provenance & Evidence