Cyclopentanone → HCID 66743778, compound

Participants

Reaction Steps

A mixture of 3-(methylamino)-5-(pyridin-4-yl)thiophene-2-carboxamide (300 mg, 1.29 mmol), p-toluenesulfonic acid monohydrate (120 mg) and cyclopentan-1-one (10 mL) in toluene (30 mL) was heated to reflux overnight. After removal of the solvent, the residue was purified by column chromatography on silica gel (MeOH: DCM=1:9) to afford the title compound (200 mg, yield 52%) as an orange solid:

Provenance & Evidence