Acetone → HCID 66743809, compound

Participants

Reaction Steps

A mixture of 3-(methylamino)-5-(pyridin-4-yl)thiophene-2-carboxamide (400 mg, 1.72 mmol), p-toluenesulfonic acid monohydrate (150 mg) and acetone (40 mL) in toluene (40 mL) was heated to reflux overnight. After removal of the solvent, the residue was purified by column chromatography on silica gel (MeOH: dichloromethane=1:9) to afford the title compound (30 mg, yield 6%) as an orange solid:

Provenance & Evidence